Publications

Pinan-Lucarre B, Gabel CV, Reina CP, Hulme SE, Shevkoplyas SS, Slone RD, Xue J, Qiao Y, Weisberg S, Roodhouse K, Sun L, Whitesides GM, Samuel A, Driscoll M. The Core Apoptotic Executioner Proteins CED-3 and CED-4 Promote Initiation of Neuronal Regeneration in Caenorhabditis elegans. PLoS Biol. 2012 May;10(5):e1001331. Epub 2012 May 22. PubMed PMID: 22629231.

Research highlights: Neuronal regeneration: a role for apoptotic proteins

Yu, S. and Driscoll, M. 2011.  EGF signaling comes of age: promotion of healthy aging in C. elegans. Exptl. Gerontol. 46:129-134.

Chatzigeorgiou, M., Grundy, S., Kindt, K., Lee, W-H, Driscoll, M and Schafer, W.R. 2010 Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.  J. Neurophys. 104:3334-3344.

Chatzigeorgiou, M., Yoo, S., Watson, J.D., Lee, W.-H., Clay Spencer, W., Kindt, K.S., Hwang, S.W., Miller III, D.M., Treinin, M., Driscoll, M., and Schafer, W. 2010. Specific roles for DEG/ENaC and TRP channels in mechanical and thermal sensation in C. elegans polymodal nociceptors. Nature Neurosci. 13:861-868.

Iwasa, H., Yu, S., Xue, J. and Driscoll, M. 2010. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-γ and IP3R activation. Aging Cell 4:490-505.

Onken, B and Driscoll, M. 2010. Metformin induces both a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via an AMPK, LKB1, and SKN-1-dependent mechanism. PLoS One 5:e8758, pp. 1-12.

Mojsilovic-Petrovic, J., Nedelsky, N., Boccitto, M., Mano, I., Georgiades, S.N. , Zhou, W., Liu, W., Neve, R.N., Taylor, J.P., Driscoll, M., Clardy, J., Merry, D. and Kalb, R.G. 2009. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 29:8236-8247.

Ibanez-Ventoso, C. and Driscoll, M. 2009. MicroRNAs in C. elegans aging:  Molecular insurance for robustness? Curr. Genomics. 10:144-154.

Mano, I., Straud, S. and Driscoll, M. 2009 C. elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity, J. Neurochem., 108:1373-1384.

Wang Y, Apicella A Jr, Lee SK, Ezcurra M, Slone RD, Goldmit M, Schafer WR, Shaham S, Driscoll M, Bianchi L. 2008. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.  EMBO J. 27:2388-2399.

Zhang, W., Bianchi, L., Lee, W. Wang, Y. and Driscoll, M. 2008. Inter-subunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity, Cell Death Diff. 15:1794-1803.

Ibanez-Ventoso, C., Vora, M. and Driscoll, M. 2008. Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology.  PLoS ONE, 3: e2818, p1-23.

Blum, E.S., Driscoll, M. and Shaham, S. 2008. Noncanonical death programs in the nematode Caenorhabditis elegans.  Cell Death Diff. 7: 15:1124-1131.

Hansen, M., Chandra, Al, Mitic, L.L, Onken, B., Driscoll, M. and Kenyon, C.  2008.  A role for autophagy genes in the extension of lifespan by dietary restriction in C. elegans, PLoS Genetics, 4:e24, p1-14.

Tsechpenakis, G. Bianchi, L., Metaxis, D., Driscoll, M. 2008. A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments. IEEE Transactions on Biomedical Engineering. 55: 1539-1549.

Mano, I., Straud, S. and Driscoll, M.  2007.  Glutamate clearance strategies impact behavior and learning in the C. elegans nervous system.  J. Biol. Chem J. Biol. Chem. 282: 34412-34419.

Tsechpenakis, G., Bianchi, L., Driscoll, M. and Metaxas, D. 2007. Tracking C. elegans populations in fluid environments for the study of different locomotory behaviors. In: 2nd. International Workshop on Microscopic Image Analysis with Applications in Biology, Piscataway, NJ.

Frokjaer-Jensen C, Kindt KS, Kerr RA, Suzuki H, Melnik-Martinez K, Gerstbrein B, Driscoll M, Schafer WR. 2006. Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons.  J Neurobiol. 66: 1125-1139.

Bianchi, L. and Driscoll, M.  2006.  Heterologous expression of C. elegans ion channels in Xenopus oocytes  WORMBOOK http://www.wormbook.org/chapters/www_channelexpress/channelexpress.html

Bianchi, L. and Driscoll, M.  2006.  Culture of Embryonic C. elegans Cells for Electrophysiological and Pharmacological Analyses”.  WORMBOOK

Ibanez-Ventoso, C., Yang, M., Guo, S., Robins, H., Padgett, R., and Driscoll, M. 2006. Modulated microRNA expression during adult lifespan in C. elegans.   Aging Cell, 5:235-246.

Royal, D.C., Bianchi, L., Royal, M., Lizzio, M., Mukherjee, G., Nunez, Y. and Driscoll, M.  2005.  Temperature-sensitive mutant of the C. elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface  maintenance.  J. Biol. Chem. 280: 41976-41986.

Gerstbrein, B., Stamatas, G., Kollias, N., and Driscoll, M.  2005. Analysis of in vivo autofluorescence in C. elegans identifies novel aging biomarkers that report healthspan and dietary restriction. Aging Cell, 4: 127-137.

Bianchi, L., Gerstbrein, B., Royal, D., Xue, J. and Driscoll, M.  2004. The neurotoxic MEC-4(d) Na+ channel conducts calcium: implications for normal and aberrant activities of DEG/ENaC channels. Nature Neurosci., 7: 1337-1344.

Bianchi, L. and Driscoll, M.  2004.  The molecular basis of touch sensation as modeled in Caenorhabditis elegans.  in Transduction Channels in Sensory Cells.  Wiley VCH. Frings, S. and Bradley, J.  eds., pp. 1-29.

Driscoll, M. and Gerstbrein, B.  2003. Dying for a cause: Invertebrate genetics takes on human neurodegeneration.  Nature Rev. Genet. 4: 181-194.

Bianchi, L., Kwok, S., Driscoll, M. and Sesti, F. 2003. A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.  J. Biol. Chem. 278: 12415-12424.

Suzuki, H., Kerr, R., Bianchi, L., Frokjar-Jensen, C., Sloan, R., Xue, J., Gerstbrein, B., Driscoll, M. and Schafer, W.R. 2003. In vivo functional analysis of C. elegans mechanosensory neurons defines a specific role for the MEC-4 channel in gentle touch sensation. Neuron 39: 1005-1017.

Thieringer, H.A., Moller, B., Dodt, G., Kunau, W.-H., and Driscoll, M. 2003. Modeling the human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.  J. Cell Science 116: 1797-1804.

Herndon, L.A., Schmeissner, P., Dudaronek, J, Listner, K.M., Brown, P.A., Sakano, Y., Paupard, M., Hall, D. and Driscoll, M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. 2002. Nature 419: 808-14.

Syntichaki, P., Xu, K., Driscoll, M., Tavernarakis, N.  2002. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.  Nature 419: 939-944.

Tavernarakis, N. and Driscoll, M.  2002. Caloric restriction and lifespan: a role for protein turnover? Mech Ageing Dev. 123: 215-229.

Bianchi, L. and Driscoll, M. 2002. Protons at the gate: DEG/ENaCs help us feel and remember. Neuron 34: 337-340.

Tavernarakis, N and Driscoll, M.  2001. Degenerins:  At the core of metazoan mechanotransduction? Ann NY Acad Sci., 940: 28-41.

Tavernarakis, N. and Driscoll, M. 2001.  Mechanotransduction in C. elegans: the role of DEG/ENaC ion channels. Cell. Biochem. Biophys. 35: 1-18.

Tavernarakis, N., Everett, J. K., Kyrpides. N. and Driscoll, M.  2001. Features of the intracellular amino-termini of DEG/ENaC ion Channels.  Curr. Biol. 11: R205-R208.

Xu, K., Tavernarakis, N. and Driscoll, M. 2001. Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca2+ release from the endoplasmic reticulum. Neuron 31: 957-971.

Herndon, L.A. and M. Driscoll.  2000.  Contributions of cell death to aging in C. elegans.  Results and Problems in Cell Differentiation, 29: 113-129.  in Molecular Biology of Aging. (ed. S. Hekimi), Springer-Verlag, Berlin.

Fricke, B., Lints, R., Stewart, G., Drummond, H., Dodt, G., Driscoll, M.  and v. Düring, M.  2000.  ENaC and stomatin are expressed in rat trigeminal mechanosensory neurons. Cell and Tissue Res. 299: 327-334.

Hong, K., Mano, I. and Driscoll, M.  2000.  Structure/function analysis of C. elegans mec-4, a component of a Na+ channel required for mechanotransduction.  J. Neurosci. 20: 2575-2588.

Tavernarakis, N. and Driscoll, M.  2000.  Caenorhabditis elegans degenerins and vertebrate ENaC ion channels contain an extracellular domain related to venom neurotoxins.  J. Neurogenet. 13: 257-264.

Driscoll, M. and Tavernarakis, N.  2000. Closing in on a mammalian touch receptor.  Nature Neurosci. 3: 7-9.

Ledwich, D., Wu, Y.C., Driscoll, M., and Xue, D. 2000.  Methods for the study of programmed cell death in the nematode Caenorhabditis elegans. Meth. Enzymol. 322: 76-88.

Chung, S., Gumienny, T., Hengartner, M. and Driscoll, M. 2000. C. elegans apoptotic and necrotic cell corpses are removed by activities of a common set of engulfment genes. Nature Cell Biol. 2: 931-937.

Tavernarakis, N., Wang, S., Dorovokov, M., Ryazanov, A. and Driscoll, M.  2000.   Heritable and inducible genetic interference by double stranded RNA encoded by transgenes. Nature Genetics 24: 180-183. 

Winnier, A.R., Meir, J.Y.-J., Ross, J.M., Ishihara, I., Tavernarakis, N., Driscoll, M., and Miller, D.M., III.  1999.  UNC-4 and UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Genes Dev. 13: 2774-2786.

Mano, I. and Driscoll, M. 1999.  The DEG/ENaC Channels:  A touchy superfamily that watches its salt. Bioessays 21: 568-578.

Tavernarakis, N., Driscoll, M. and Kyrpides, N.C. 1999. The SPFH domain: a universal motif in stomatins and other membrane-associated proteins implicated in regulating targeted protein turnover.  TiBS 24: 425-427.

Royal, D. and Driscoll, M.  1998.  Neuronal cell death in C. elegans.  In: Cell Death in Diseases of the Nervous System (ed. V.E. Koliatsos and R. Ratan) The Humana Press Inc., Totowa, N.J. pp. 123-144.

Tavernarakis, N. and Driscoll, M.  1997.  Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans.  Annu. Rev. Physiol. 59: 659-689.

Tavernarakis, N., Shreffler, W., Wang, S. and Driscoll, M.  1997. unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically-gated channel that modulates locomotion in C. elegans. Neuron 18: 107-119. 

Hall, D.H., Gu, G., Garcia-Anoveros, J., Gong, L., Chalfie, M. and Driscoll, M.  1997.  Neuropathology of degenerative cell death in C. elegans.   J. Neurosci. 3: 1033-1045.

Harbinder, S., Tavernarakis, N., Herndon, L., Kinnell, M., Xu, S.Q., Fire, A. and Driscoll, M.  1997.  Genetically targeted cell disruption in Caenorhabditis elegans.  Proc. Natl. Acad. Sci USA 94: 13128-13133.

Driscoll, M. and Kaplan, J. 1997. Mechanotransduction, in "The Nematode C. elegans, II".  Cold Spring Harbor Press, Cold Spring Harbor, NY., pp. 645-677.

Lints, R. and Driscoll, M. 1996.  Programmed and Pathological Cell Death in C. elegans.   in "Cell Aging and Cell Death", Martin, G.R., Holbrook, N. and Lockshin, R.A., eds., Wiley-Liss, New York.  pp. 235-253. 

Lai, C. C. Hong, K., Kinnell, M., Chalfie, M. and Driscoll, M.  1996. Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in C. elegans.

Driscoll, M. 1996.  Cell Death in C. elegans: Molecular insights into mechanisms conserved between nematodes and mammals.  Brain Path. 6: 411-425.

Driscoll, M.  1995.  Methods for the study of cell death in C. elegans.  Meth. Cell. Biol.  46: 323-353.

Driscoll, M.  1995.  Genes controlling programmed cell death:  Relation to mechanisms of cell senescence and aging?  Dahlem Workshop Reports, Molecular Aspects of Aging, John Wiley and Sons, Chichester, pp. 45-58. 

Mariq, A.D., Peckol, E., Driscoll, M. and Bargmann, C.I.  1995.  Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor.  Nature 378: 78-81.

Driscoll, M.  Inherited neurodegeneration in C. elegans. 1994.   in "Neurodegenerative Diseases", Jolles, G. and Stultzmann, J.M., eds. Academic Press (London) pp. 3-22.

Hong, K. and Driscoll, M.  1994.  A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.  Nature 367: 470-473.

Mitani, S., Du, H., Hall, D., Driscoll, D. and Chalfie, M. 1993. Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 19: 773-783.

Chalfie, M., Driscoll, M. and Huang, M.  Degenerin similarities. 1993.  Nature 361: 504.

Katz, L.C., Driscoll, M., Zimmerman, K. and Wiesel, T.N.  1992.  Neural development.  Brain Research Reviews 17: 171-181.

Driscoll, M. and Chalfie, M.  1992.  Developmental and abnormal cell death in Caenorhabditis elegans.  Trends Neurosci. 15: 15-19.

Driscoll, M.  1992.  Molecular genetics of cell death in C. elegans.  J. Neurobiol. 23: 1327-1351.

Driscoll, M. and Chalfie, M.  1991.  The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.  Nature 349: 558-593.

 S. Kanazawa, S., Driscoll, M., and Struhl, K. 1988.  ATR1, a Saccharomyces cerevisiae transmembrane protein required for aminotriazole resistance.  Mol. Cell. Biol. 8: 664-673.

Driscoll Penn, M., Thireos, G.  and Greer, H.  1984.   Temporal analysis of general control of amino acid biosynthesis in Saccharomyces cerevisiae:  role of positive regulatory genes in initiation and maintenance of mRNA depression.  Mol. Cell. Biol. 4: 520-528.

Thireos, G.,  Driscoll Penn, M., and Greer, H.  1984. 5' untranslated sequences are required for the translational control of a yeast regulatory  gene.  Proc. Natl. Acad. Sci. USA 81: 5096-5100.

Driscoll Penn, M., Galgoci, B. and Greer, H. 1983.  Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast.  Proc. Natl. Acad. Sci. USA 80: 2704-2708.